Evolution of coronary artery calcium and absolute myocardial perfusion after percutaneous revascularization: a 3-year serial hybrid [15O]H2O PET/CT imaging study

Abstract Funding Acknowledgements Type of funding sources: None. Background. The value serial coronary artery calcium (CAC) scores to predict changes in absolute myocardial perfusion and epicardial vasomotor function is poorly documented. Purpose. This study explored the association between progression CAC score perfusion. Methods. Fifty-three patients with single-vessel disease (CAD) underwent [15O]H2O Positron Emission Tomography/Computed Tomography at 1 month (baseline), year, 3 years after percutaneous intervention (PCI) assess scores, hyperemic blood flow (hMBF), reserve (CFR) cold pressor test MBF (CPT-MBF), within context VANISH (Impact Vascular Reparative Therapy on Vasomotor Function Myocardial Perfusion) trial. Relationships baseline evolution indices were a mixed model-analysis. Results. Baseline was 0 9%, 0.1-99.9 40%, 100-399.9 36% ≥400 15% patients, respectively. In higher groups, increased more over time (overall p < 0.01). Mixed model-analysis allowed for averaging all points: hMBF (3.74 ± 0.83; 3.33 0.79; 3.08 0.78 2.44 0.74 mL·min-1·g-1) CFR (3.82 1.12; 3.17 0.80; 3.19 0.81; 2.63 0.92) lower among groups (p 0.01; = 0.03). However, no significant interaction found PCI indices, denoting that not significantly different groups. Furthermore, correlated (r 0.08, 0.57), 0.09, 0.53) or CPT-MBF 0.03, 0.82) during follow-up. Conclusions. Higher associated CFR. both its hMBF, time, suggesting are poor indicators change